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Recent developments on ketolides and macrolides.

Y J Wu·W G Su
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Abstract

Recent semi-synthetic studies of erythromycin A culminated in the discovery of two ketolide drug candidates, HMR-3647 and ABT-773, for the treatment of community-acquired bacterial infections caused by both macrolide- and beta-lactam-susceptible and -resistant S. pneumoniae, gram negative bacteria, and intracellular atypical pathogens. The discovery of ketolides has rekindled interest in macrolides, and recent efforts have also led to a novel class of 4''-carbamates with activity against macrolide-resistant organisms. This review is an account of recent developments on ketolides and macrolides in terms of both chemistry and antibacterial activity.

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AnimalsAnti-Bacterial AgentsCarbamatesDrug DesignDrug Evaluation, PreclinicalErythromycinKetolidesKetonesMacrolidesStructure-Activity RelationshipJournal ArticleReview

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Y J Wu, W G Su. 2001. Recent developments on ketolides and macrolides.. https://doi.org/10.2174/0929867013371671

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