Rolling circle amplification for scoring single nucleotide polymorphisms.

A Rösler; L Bailey; S Jones; J Briggs; S Cuss; I Horsey; M Kenrick; S Kingsmore; L Kent; J Pickering; T Knott; E Shipstone; G Scozzafava

doi:10.1081/ncn-100002453

PubMed · 11563139

Rolling circle amplification for scoring single nucleotide polymorphisms.

A Rösler·L Bailey·S Jones·J Briggs·S Cuss·I Horsey·M Kenrick·S Kingsmore·L Kent·J Pickering·T Knott·E Shipstone·G Scozzafava

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Abstract

The analysis of the genetic basis of phenotypic traits is moving towards the complex diseases prevalent in wealthy populations. There is an increasing requirement for the detection of different types of sequence variation, particularly single-nucleotide polymorphisms (SNPs). SNPs occur about once every 100 to 300 bases. High-density SNP maps will help to identify the multiple genes associated with complex diseases such as cancer, diabetes, vascular disease, and some forms of mental illness.

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DNA Genetic Predisposition to Disease Humans Polymorphism, Single Nucleotide Journal Article

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A Rösler, L Bailey, S Jones, J Briggs, S Cuss, I Horsey, M Kenrick, S Kingsmore, L Kent, J Pickering, T Knott, E Shipstone, G Scozzafava. Rolling circle amplification for scoring single nucleotide polymorphisms.. https://doi.org/10.1081/ncn-100002453

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