Wobble base-pairing in codon-anticodon interactions: a theoretical modelling study.

S U Mangang; R H Lyngdoh

PubMed · 11563322

Wobble base-pairing in codon-anticodon interactions: a theoretical modelling study.

Abstract

The Crick wobble hypothesis attributes the phenomenon of codon degeneracy to a certain impreciseness of pairing between the third base of the codon and the first base of the anticodon. This theoretical study investigates the pairing properties of some wobble bases, including both, observed and unobserved pairs. Some wobble base-pairs are predicted to follow the Watson-Crick pairs in configuration and pairing facility, while others deviate from this norm. The observed U:V pair is unique in that a pairing configuration may be suggested for it wherein the hydrogen-bonding involves the exocyclic 5-carboxymethoxy group of V. By comparing the theoretical data on the configurations of these pairs with the evidence for their existence/non-existence in nature, some guidelines emerge for differentiating between observed and unobserved base pairs on the basis of the pairing configuration.

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Adenine Anticodon Base Pairing Codon Computer Simulation Cytosine DNA Guanine Hydrogen Bonding Inosine Models, Chemical Nitrogen Nucleic Acid Conformation Uracil Journal Article Research Support, Non-U.S. Gov't

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S U Mangang, R H Lyngdoh. Wobble base-pairing in codon-anticodon interactions: a theoretical modelling study.. https://pubmed.ncbi.nlm.nih.gov/11563322/

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