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PubMed · 1156558

The HL-A system and psoriasis.

J C Woodrow·V K Dave·N Usher·J Anderson
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Abstract

A study of 157 psoriatic patients showed that 48.4% were HL-A 17 positive (control 6.0%). The relative risk of psoriasis in HL-A 17 positive individuals (14.7) was significantly higher than that reported from other centes, whilst that for HL-A 13 was lower. HL-A 17 was commoner in femal patients and associated with an earlier age of onset of psoriasis than when HL-A 17 was absent. The earlier age of onset in females is largely due to the higher frequency of HL-A 17. Family studies show that often the ingeritance of HL-A 17 is a necessary condition for psoriasis to appear and this probably applies in some instances to HL-A 13. It is likely that there is interaction between HL-A 17 and HL-A 13 and other genes predisposing to psoriasis. In some families there appears to be no association between psoriasis and the HL-A system. The general significance of these findings is discussed.

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Age FactorsGene FrequencyHLA AntigensHistocompatibility AntigensHumansJoint DiseasesPedigreePhenotypePsoriasisSex FactorsJournal Article

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BibTeXRIS

J C Woodrow, V K Dave, N Usher, J Anderson. 1975. The HL-A system and psoriasis.. https://doi.org/10.1111/j.1365-2133.1975.tb03104.x

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