Dendritic cell-dead cell interactions: implications and relevance for immunotherapy.

J F Fonteneau; M Larsson; N Bhardwaj

doi:10.1097/00002371-200107000-00005

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PubMed · 11565831

Dendritic cell-dead cell interactions: implications and relevance for immunotherapy.

J F Fonteneau·M Larsson·N Bhardwaj

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Abstract

Dendritic cells are a system of antigen-presenting cells with an essential role in the initiation and development of immune responses against infections or tumors. Their unique capacity to stimulate T cells is being adapted for use in immunotherapy. In this review, we focus on their ability to interact with dead cells and, notably, to present exogenous antigens acquired from them to CD8+ T cells. We also discuss the role of this unique antigen presentation pathway for immunotherapeutic development.

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Antigen-Presenting Cells Apoptosis Cell Communication Cell Death Dendritic Cells HLA Antigens Humans Immunotherapy T-Lymphocytes, Cytotoxic Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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J F Fonteneau, M Larsson, N Bhardwaj. Dendritic cell-dead cell interactions: implications and relevance for immunotherapy.. https://doi.org/10.1097/00002371-200107000-00005

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