Intravesical oxybutynin affects bladder permeability.

A Ersay; O C Demirtas

doi:10.1023/a:1017595401988

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PubMed · 11583352

Intravesical oxybutynin affects bladder permeability.

A Ersay·O C Demirtas

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Abstract

To investigate the effects of intravesical application of oxybutynin chloride on bladder permeability we designed an animal model. Female Guinea pigs were given 3 different test solutions: phosphate buffered saline (PBS), 50% acetone and 1.27 x 10(-2) M oxybutynin chloride solution. Then 99mTc-DTPA 45 microCi in 2 ml normal saline was instilled into the bladder lumen in each animals and allowed to dwell for 30 minutes. At the end of exposure time, the net count data in each 1 ml serum sample were corrected for radioactive decay and converted to the total percentage of administered dose. 99mTc-DTPA absorption percentages of both acetone and oxybutynin groups were significantly higher than that of PBS group (mean 3.2 +/- 2.9% p < 0.001). Intravesical oxybutynin application increases bladder permeability 5 times compared with PBS administration. This observation can also explain how rapid absorption of oxybutynin through the bladder into the systemic circulation occurs.

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Administration, Intravesical Animals Cell Membrane Permeability Female Guinea Pigs Mandelic Acids Models, Animal Radiopharmaceuticals Technetium Tc 99m Pentetate Urinary Bladder Journal Article

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A Ersay, O C Demirtas. 2001. Intravesical oxybutynin affects bladder permeability.. https://doi.org/10.1023/a%3A1017595401988

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