PubMed · 11584742
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P L Olliaro, R Vijayan, K Inbasegaran, C C Lang, S Looareesuwan. 2001. Drug studies in developing countries.. https://pubmed.ncbi.nlm.nih.gov/11584742/
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Incremental progress will likely continue to be made in the treatment of lung cancer using the conventional treatment modalities. However, there is now hope that the development of noncross-resistant modalities that can be accomplished using the technology of gene transfer may hasten the progress made in this disease. Although significant progress has been made, the practical application of the various strategies to the treatment of cancer patients in clinical trials has yielded only very limited results. For the strategies of introducing suicide genes, replacing defective tumor-suppressor genes, and inactivating oncogenes, considerable progress will need to be made particularly with regard to the ability of vectors to selectively and efficiently target tumor cells in order for many of these strategies to become effective. With regard to the application of gene therapy to immunotherapy, major responses are not likely at this time since these innovative therapies are being developed in patients with advanced disease. However, it is very likely that these pioneering clinical trials will provide important clinical and immunological information that will be the basis for future attempts to effectively harness the immune system against lung cancer.
The WHO Influenza Surveillance Programme has recently celebrated 50 years of success. The programme provides representative influenza viruses for antigenic and genetic analysis and from this information, the WHO is able to make recommendations on vaccine composition. The WHO has also a key important role to play in detecting new influenza pandemic viruses and advising on suitable vaccine strains and their use. Experience in developing vaccines for pandemics or pandemic alerts in the past, has informed us that there are considerable problems to solve, not least of which is the fact that the conventional vaccines used throughout the world are unlikely to be effective in the face of a pandemic. Different strategies need developing and testing, so that we are adequately prepared.
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