p38 MAP kinase activity modulates alpha beta T cell development.

T Mulroy; J Sen

doi:10.1002/1521-4141(2001010)31:10<3056::aid-immu3056>3.0.co;2-b

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p38 MAP kinase activity modulates alpha beta T cell development.

T Mulroy·J Sen

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Abstract

Reciprocal interactions between bone marrow derived precursor cells and the thymic environment lead to the generation of the complete repertoire of diverse and functional T cells. We have previously shown that p38 MAP kinase is activated in response to intrathymic signals in thymocytes. In this report we provide evidence that p38 MAP kinase activity is essential for pre-TCR-mediated transition of thymocytes from the CD4- CD8- to the CD4+ CD8+ stage of development. In the absence of p38 MAP kinase activity differentiation of alpha beta T cells, but not gamma delta T cells, was blocked.

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Animals CD4 Antigens CD8 Antigens Hyaluronan Receptors Mice Mice, Inbred BALB C Mitogen-Activated Protein Kinases Receptors, Antigen, T-Cell, alpha-beta Receptors, Antigen, T-Cell, gamma-delta Receptors, Interleukin-2 Signal Transduction T-Lymphocytes p38 Mitogen-Activated Protein Kinases Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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T Mulroy, J Sen. 2001. p38 MAP kinase activity modulates alpha beta T cell development.. https://doi.org/10.1002/1521-4141(2001010)31%3A10%3C3056%3A%3Aaid-immu3056%3E3.0.co%3B2-b

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