Human migraine models.

H K Iversen

doi:10.1111/j.1468-2982.2001.00250.x

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Human migraine models.

H K Iversen

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Abstract

The need for experimental models is obvious. In animal models it is possible to study vascular responses, neurogenic inflammation, c-fos expression etc. However, the pathophysiology of migraine remains unsolved, why results from animal studies not directly can be related to the migraine attack, which is a human experience. A set-up for investigations of experimental headache and migraine in humans, has been evaluated and headache mechanisms explored by using nitroglycerin and other headache-inducing agents. Nitric oxide (NO) or other parts of the NO activated cascade seems to be responsible for the induced headache and migraine. Perspectives are discussed.

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Animals Cerebrovascular Circulation Humans Migraine Disorders Models, Neurological Nitroglycerin Vasodilator Agents Journal Article Review

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H K Iversen. 2001. Human migraine models.. https://doi.org/10.1111/j.1468-2982.2001.00250.x

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