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PubMed · 11600399

Staphylococcus aureus mutants selected by BMS-284756.

L F Discotto·L E Lawrence·K L Denbleyker·J F Barrett
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Abstract

BMS-284756, a novel des-fluoro(6)-quinolone, was used to select for in vitro mutants of Staphylococcus aureus ISP794. Step mutants were obtained, and the quinolone resistance-determining regions of four target genes, gyrA, gyrB, grlA, and grlB, were sequenced. The data suggest that DNA gyrase is the primary target for BMS-284756 in S. aureus.

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Anti-Infective AgentsCiprofloxacinDNA GyraseDNA, BacterialDrug Resistance, MicrobialFluoroquinolonesIndolesMutationQuinolonesReverse Transcriptase Polymerase Chain ReactionStaphylococcus aureusJournal Article

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L F Discotto, L E Lawrence, K L Denbleyker, J F Barrett. 2001. Staphylococcus aureus mutants selected by BMS-284756.. https://doi.org/10.1128/aac.45.11.3273-3275.2001

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