PubMed · 11625969
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I Simon. 1974. [Not Available].. https://pubmed.ncbi.nlm.nih.gov/11625969/
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PURPOSE: To describe the frequency and magnitude of late GI and GU morbidity in prostate cancer patients treated to high dose levels with a simple three-dimensional conformal technique. METHODS AND MATERIALS: A total of 156 intermediate- and high-risk patients were treated between January 1, 1992 and February 28, 1999 with a simple four-field three-dimensional conformal technique to 79-84 Gy. All patients were treated with a four-field conformal technique; the prostate received 82 Gy and the seminal vesicles and periprostatic tissue 46 Gy. GI and GU toxicity was scored according to the Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer Late Morbidity Grading Scale and compared using Kaplan-Meier estimates. RESULTS: The late Grade 2 GI complication rate was 9% and 38% at 3 years for patients treated with and without rectal blocking, respectively (p = 0.0004). No Grade 3 late GI complications developed. The rate of Grade 2 late GU complications was 5%, 8%, and 12% at 12, 24, and 36 months, respectively. The Grade 3 late GU complication rate was 2% at 36 months. These differences were not statistically significant. CONCLUSION: The treatment method described is a simple four-field conformal technique that can be easily implemented in the general radiation community. A dose of 79-84 Gy can be safely delivered to the prostate, with a 9% rate of late Grade 2 GI, 12% rate of late Grade 2 GU, and 2% rate of late Grade 3 GU complications.
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Motility of the gastrointestinal tract includes the phenomena of contractile activity, tone, compliance, flow, and transit. Sensitivity of the gastrointestinal tract is intimately related to motility. A range of techniques, both invasive and noninvasive, can be applied to evaluate enteric sensorimotor function in health and disease. This article reviews the physiologic principles underpinning these techniques. Altertions in both sensitivity and motility are believed to be important in the origin of symptoms in the functional gastrointestinal disorders. The evolution of studies investigating motility and sensitivity in these disorders, using the previously mentioned techniques, is also considered.