Pharmacokinetics and Eigenvector decomposition. Two-compartment open system after rapid intravenous administration.

P J Lewi

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PubMed · 1164093

Pharmacokinetics and Eigenvector decomposition. Two-compartment open system after rapid intravenous administration.

P J Lewi

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Abstract

The theroetical background of linear pharmacokinetics is presented in terms of elementary mathematical operations while preserving the important aspects of eigenvector decomposition. The discussion is limited to two-compartment open models with rapid intravenous administration. Eigenvector decomposition allows to extend the theory in a straightforward manner to models of higher order and to other ways of administration. A computational scheme is included that can be carried out on a desk-calculator in a small number of steps.

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Biodegradation, Environmental Half-Life Injections, Intravenous Kinetics Mathematics Models, Biological Pharmaceutical Preparations Journal Article

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P J Lewi. 1975. Pharmacokinetics and Eigenvector decomposition. Two-compartment open system after rapid intravenous administration.. https://pubmed.ncbi.nlm.nih.gov/1164093/

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