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PubMed · 1164110

Autoimmune hemolytic anemia.

J V Dacie
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Abstract

Warm-type autoantibodies of autoimmune hemolytic anemia (AIHA) are usually IgG but may be IgM or IgA. They are usual Rh specific. Cold-type antibodies are IgM or IgG (Donath-Landsteiner [DL] antibody). IgM antibodies are usually anit-l (occasionally anti-i) and DL antibodies anti-P. The warm IgG antibodies do not fix complement (C); they cause red blood cell (RBC) destruction predominantly in the spleen as the result of interaction between fixing; they cause RBC destruction either by intravascular lysis (complement sequence completed) or by interaction between C3-coated RBCs and phagocytes in liver and spleen. Gentic factors, immunoglobulin deficiency, somatic mutation, viral infections and drugs, and failure of T-lymphocyte function, all probably play a part in breaking immunological tolerance and the development of AIHA.

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Anemia, Hemolytic, AutoimmuneAutoantibodiesCold TemperatureErythrocytesHumansImmunoglobulin AImmunoglobulin GImmunoglobulin MImmunologic Deficiency SyndromesInfectionsLymphomaMethyldopaPhagocytesSpleenThymectomyJournal Article

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J V Dacie. 1975. Autoimmune hemolytic anemia.. https://pubmed.ncbi.nlm.nih.gov/1164110/

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