Tobramycin ototoxicity: a second look.

R E Brummett; R T Brown

doi:10.1001/archotol.1975.00780380018004

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Tobramycin ototoxicity: a second look.

R E Brummett·R T Brown

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Abstract

Tobramycin was administered intravenously to guinea pigs and was shown to produce an impairment of the alternating current cochlear potential. This effect is temporary and occurs only when the blood pressure has been severely lowered. We conclude that these data do not represent the onset of ototoxicity of tobramycin as reported by others, but only represents the cochlear effect of the pronounced fall in blood pressure that is produced by the tobramycin.

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Action Potentials Animals Anti-Bacterial Agents Blood Pressure Cochlea Ear Guinea Pigs Injections, Intravenous Injections, Subcutaneous Time Factors Tobramycin Journal Article

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R E Brummett, R T Brown. 1975. Tobramycin ototoxicity: a second look.. https://doi.org/10.1001/archotol.1975.00780380018004

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