PubMed · 11644204
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
Bryan Jennett, Ian M Kennedy. 1981-03-07. The brain death debate.. https://doi.org/10.1016/s0140-6736(81)92900-7
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
Poly(ADP-ribose)polymerase-1 (PARP-1) is a nuclear protein activated by DNA damage. PARP-1 activation is associated in DNA repair, cell death and inflammation. Since oxidative stress induced robust DNA damage and wide spread inflammatory responses are common pathologies of various CNS diseases, the interest toward PARP-1 as a therapeutic target has peaked. This review introduces mechanism of PARP-1 activation, the role of PARP-1 in cell physiology and pathology, and discusses the potential of PARP-1 inhibition as a therapy in acute and chronic CNS diseases.
Explore the source record for details and available documents.
Explore the source record for details and available documents.