PubMed · 1164606
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1975-08-30. Editorial: Brain abscess.. https://pubmed.ncbi.nlm.nih.gov/1164606/
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The case of a newborn infant who developed meningitis caused by E. coli is presented. During i.v. treatment with ampicillin and gentamycin in recommended doses and according to susceptibility patterns, the patient developed cerebral abscesses detected on CT. After changing to third generation cephalosporin, the patient improved clinically and the CT-changes regressed and disappeared. Because of their superior bactericidal effect, we recommend a third generation cephalosporin as a first choice in the treatment of neonatal E. coli meningitis.
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The authors report a rare case of cryptogenic osteomyelitis of the skull with an intracerebral and a subgaleal abscess. Total excision of the abscess extending from the cortical surface to the lateral ventricle led to ventriculitis and subgaleal cerebrospinal fluid collection. These complications could have been avoided by aspirating the abscess after removing the infected portion of the skull and the epidural granulation tissue. Neurosurgeons preferring to excise such an abscess should leave a small area of capsule at the base in order to avoid having to open the ventricle.