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PubMed · 11683122

Fentanyl-selective polymeric membrane electrode.

L J Peng·M L Wen·Y Yao
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Abstract

A poly (vinyl chloride) membrane electrode with dibutyl phthalate as plasticizer based on a fentanyl-tetrakis(4-chlorophenyl)borate ion-pair complex for the determination of fentanyl citrate in injections is described. A linear response over the range 1 x 10(-5) mol.dm-3 to 1 x 10(-2) mol.dm-3 drug with a slope of 59.3 +/- 0.6 mV/decade was established. The optimum pH range was 1 to 6. The lower detection limit was 8 x 10(-6) mol.dm-3 fentanyl citrate (2.7 micrograms cm-3 fentanyl). There were negligible interferences from a number of inorganic cations, structural analogues, and some common drug additives used in injections. The electrode proposed has been successfully applied to determine fentanyl citrate in injections. The results correlated well with those obtained by the United States Pharmacopoeia standard procedure.

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Chromatography, High Pressure LiquidDibutyl PhthalateElectrodesFentanylHydrogen-Ion ConcentrationIndicators and ReagentsMembranes, ArtificialPlasticizersPolymersPolyvinyl ChloridePotentiometryTetraphenylborateJournal ArticleResearch Support, Non-U.S. Gov't

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L J Peng, M L Wen, Y Yao. 2001. Fentanyl-selective polymeric membrane electrode.. https://pubmed.ncbi.nlm.nih.gov/11683122/

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