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PubMed · 11683424

Statins and bone: myth or reality?

C J Edwards·R G Russell·T D Spector
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Abstract

In the space of a few weeks, four articles appeared in the The Lancet and JAMA suggesting that using 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors (statins) is associated with increased bone mineral density (BMD) and a reduced fracture risk. The stimulus for these case-control studies came from reports that the statins have unexpected effects on bone, increasing bone formation in rodents. These observations offered a new insight into the potential importance of the cholesterol synthesis pathway in bone turnover and future therapeutic opportunities.

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AnimalsBone DensityBone and BonesHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMevalonic AcidJournal ArticleReview

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C J Edwards, R G Russell, T D Spector. 2001. Statins and bone: myth or reality?. https://doi.org/10.1007/s00223-001-2017-7

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