Mouse models for multistep tumorigenesis.

X Wu; P P Pandolfi

doi:10.1016/s0962-8924(01)02127-4

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PubMed · 11684435

Mouse models for multistep tumorigenesis.

X Wu·P P Pandolfi

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Abstract

The mouse is an ideal model system for studying the molecular mechanisms underlying the pathogenesis of human cancer. The generation of transgenic and gene-knockout mice has been instrumental in determining the role of major determinants in this process, such as oncogenes and tumor-suppressor genes. In the past few years, modeling cancer in the mouse has increased in its complexity, allowing in vivo dissection of the fundamental concepts underlying cooperative oncogenesis in various tumor types. In this review, we discuss how this transition has been facilitated, providing relevant examples. We also review how, in the post-genome era, novel methodologies will further accelerate the study of multi-step tumorigenesis in the mouse.

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Animals Avian Proteins Disease Models, Animal Epidermis Gene Transfer Techniques Humans Mice Mice, Knockout Mice, Transgenic Neoplasms, Experimental Receptors, Virus Skin Neoplasms Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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X Wu, P P Pandolfi. 2001. Mouse models for multistep tumorigenesis.. https://doi.org/10.1016/s0962-8924(01)02127-4

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