Specific nucleoprotein complexes within adenovirus capsids.

T Dobner; D Büchner; T Zeller; H Wolf; H H Niller

doi:10.1515/bc.2001.169

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Specific nucleoprotein complexes within adenovirus capsids.

T Dobner·D Büchner·T Zeller·H Wolf·H H Niller

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Abstract

Adenoviral DNA was examined within capsids by dimethyl sulfate footprinting. Protein-DNA interactions were visualized through ligation-mediated PCR (LM-PCR). Signals for protein binding were found adjacent to both inverted terminal repeats (ITR). There were no indications of close protein binding at several other loci of the viral genome. Therefore, adenovirus type 5 seems to contain sequence- or locus-specific DNA binding proteins within the virion.

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Adenoviridae Base Sequence Capsid DNA Footprinting DNA, Viral Humans Molecular Sequence Data Nucleoproteins Tumor Cells, Cultured Journal Article

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T Dobner, D Büchner, T Zeller, H Wolf, H H Niller. 2001. Specific nucleoprotein complexes within adenovirus capsids.. https://doi.org/10.1515/bc.2001.169

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