Technology evaluation: anticancer gene therapy, MediGene.

S Hunt

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PubMed · 11699897

Technology evaluation: anticancer gene therapy, MediGene.

S Hunt

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Abstract

MediGene is developing recombinant adeno-associated virus (rAAV) vectors for the potential treatment of cancer, and in particular, melanoma and ovarian cancer [304021]. In June 2001, MediGene and its collaborator Aventis Pharma announced the start of a phase I/II trial for a vaccine against malignant melanoma [413513]. The therapy works by boosting the patient's immune response. Autologous or allogeneic tumor cells are transduced with recombinant adeno-associated virus (rAAV) vectors, which express immunomodulators, such as cytokines, and are then expanded in vitro. Following irradiation, these gene-modified cells are reintroduced to the host, leading to a specific antitumor response against the patient's own tumor cells [221820].

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Animals Cancer Vaccines Dependovirus Female Genetic Therapy Genetic Vectors Humans Melanoma Neoplasms Ovarian Neoplasms Clinical Trial Clinical Trial, Phase I Clinical Trial, Phase II Journal Article

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S Hunt. 2001. Technology evaluation: anticancer gene therapy, MediGene.. https://pubmed.ncbi.nlm.nih.gov/11699897/

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