A partial BRCA1 sequence homology mapping to 4q28.

I Stec; M van Vliet; R van Eijk; H Meijers; K H Kroeze; J G Dauwerse; G J van Ommen; C J Cornelisse; J T den Dunnen; P Devilee

doi:10.1159/000048777

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A partial BRCA1 sequence homology mapping to 4q28.

I Stec·M van Vliet·R van Eijk·H Meijers·K H Kroeze·J G Dauwerse·G J van Ommen·C J Cornelisse·J T den Dunnen·P Devilee

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Abstract

Using a BRCA1 cDNA probe in Southern analysis, we detected a sequence of 348 bp on 4q28 that is homologous to the 3' end of BRCA1. A 28-kb sequence contig has been assembled spanning the homologous region, which we designated BRCA1-h. An open reading frame was identified encoding a sequence of 82 amino acids; 22 of the last 23 amino acids are identical to the last 23 residues of BRCA1. BLAST-searches, RT-PCR and RACE-experiments have been unable to provide evidence that BRCA1-h is part of an expressed gene.

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Amino Acid Sequence Animals Blotting, Southern Chromosomes, Human, Pair 4 Contig Mapping Exons Expressed Sequence Tags Genes, BRCA1 Humans In Situ Hybridization, Fluorescence Molecular Sequence Data Open Reading Frames Sequence Homology, Nucleic Acid Journal Article Research Support, Non-U.S. Gov't

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I Stec, M van Vliet, R van Eijk, H Meijers, K H Kroeze, J G Dauwerse, G J van Ommen, C J Cornelisse, J T den Dunnen, P Devilee. 2001. A partial BRCA1 sequence homology mapping to 4q28.. https://doi.org/10.1159/000048777

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