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PubMed · 11709073

Uncoupling protein 3 biological activity.

J P Giacobino
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Abstract

The hypothesis that uncoupling protein 3 (UCP3) is an uncoupling protein involved in heat dissipation is not unequivocally supported. An update of in vitro, ex vivo and in vivo studies testing this hypothesis is presented. Data are provided showing that exercise induces a fatty acid-dependent increase in muscle UCP3 mRNA in humans. The proposed positive correlation between glycolytic capacity and UCP3 level in various muscle-fibre types in the mouse is reassessed. Finally, an association between an intronic polymorphism of UCP3 and adiposity is reported.

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AnimalsBlotting, WesternCarrier ProteinsFood DeprivationGlucoseHumansIon ChannelsMiceMice, KnockoutMitochondriaMitochondrial ProteinsRNA, MessengerRatsTemperatureTissue DistributionUncoupling Protein 3Journal ArticleReview

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J P Giacobino. 2001. Uncoupling protein 3 biological activity.. https://doi.org/10.1042/0300-5127%3A0290774

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