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PubMed · 11709164

Intricacies in ATP-dependent clamp loading: variations across replication systems.

M A Trakselis·S J Benkovic
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Abstract

DNA replication requires the coordinated effort of many proteins to create a highly processive biomachine able to replicate entire genomes in a single process. The clamp proteins confer on replisomes this property of processivity but in turn require clamp loaders for their functional assembly onto DNA. A more detailed view of the mechanisms for holoenzyme assembly in replication systems has been obtained from the advent of novel solution experiments and the appearance of low- and high-resolution structures for the clamp loaders.

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Adenosine TriphosphateBacteriophage T4DNA ReplicationDNA-Directed DNA PolymeraseEscherichia coliModels, MolecularMolecular Motor ProteinsJournal ArticleReview

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M A Trakselis, S J Benkovic. 2001. Intricacies in ATP-dependent clamp loading: variations across replication systems.. https://doi.org/10.1016/s0969-2126(01)00676-1

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