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PubMed · 11716299

Checkpoints for vesicular traffic?

A Fiset·R Faure
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Abstract

During interphase the transport of material between different intracellular organelles requires accurate regulation of fusiogenic domains. Recent studies on hepatic endosomes indicated that compartmentalized Cdk2-cyclin E complexes act by braking fusion events. These Cdk2 complexes integrate tyrosine phosphorylation and dephosphorylation inputs, resulting in the control of the number of rounds of fusion at discrete domains. This leads to changes in the intracellular location of internalized receptors and ultimately their biological response.

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AnimalsCDC2-CDC28 KinasesCyclin ECyclin-Dependent Kinase 2Cyclin-Dependent KinasesDNAEndosomesGuanosine TriphosphateInterphaseLigandsMitosisModels, BiologicalPhosphorylationProtein Serine-Threonine KinasesProtein Structure, TertiaryProtein TransportProtein-Tyrosine KinasesSignal TransductionTyrosineJournal ArticleResearch Support, Non-U.S. Gov'tReview

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A Fiset, R Faure. 2001. Checkpoints for vesicular traffic?. https://pubmed.ncbi.nlm.nih.gov/11716299/

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