Receptor-Ck regulates giardia encystation process.

D Kaul; R Rani; R Sehgal

doi:10.1023/a:1012277001794

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Receptor-Ck regulates giardia encystation process.

D Kaul·R Rani·R Sehgal

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Abstract

The study addressed to resolve the mechanism involved in cholesterol-dependent regulation of giardia encystation process, revealed that (a) the trophozoites have the ability to express genes coding for receptor-Ck and sterol element binding protein (SREBP); (b) inhibition of cholesterol dependent activation of receptor-Ck results in the upregulation of CWP-1 gene expression leading to encystation process. Based upon these findings, we propose that receptor-Ck dependent signalling is responsible for the regulation of giardia encystation process by cholesterol.

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Animals CCAAT-Enhancer-Binding Proteins Cells, Cultured Cholesterol DNA-Binding Proteins Giardia Protozoan Proteins Receptors, Lipoprotein Sterol Regulatory Element Binding Protein 1 Transcription Factors Journal Article

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D Kaul, R Rani, R Sehgal. 2001. Receptor-Ck regulates giardia encystation process.. https://doi.org/10.1023/a%3A1012277001794

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