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PubMed · 11718006

[The experimental study of Sr-HAP on reconstructing mandibular bone defect].

Y Gu·D Liao·Z Zhou
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Abstract

OBJECTIVE: Different ration of Sr-HAP was implanted in animals to study the bioreactions in order to prepare for the clinical applications in future. METHODS: 24 rabbits were divided into 3 groups for study. Bone defect of 6 mm x 12 mm x 4 mm was made at the mandibular angle of rabbits and Sr-HAP of different proportion (10%, 5%, 0%) was applied to reform the defect. One group of animals were killed at 1 month, 3 months, 6 months to evaluate the biologic capacity with anatomy, histology, SEM, tetracycline fluorescent marker, ECT and ration histology. RESULTS: Sr-HAP had hardly been rejected by hosts, and in early period after operation the new bone in the Sr-HAP was found with great quantities as the degradation of Sr-HAP much more than that in the pure HA, and the difference of bone quantity can be shown in statistics. CONCLUSIONS: 1. Sr-HAP has a better biocompatibility, biodegradation than pure HA and a excellent osteoinductivity. The existence of Sr-HAP improves the total new bone quantity and the interface of bone, also prolongs the period of new bone increasing. 2. Sr-HAP has a good biodegradation and suitable speed of biodegradating, so the reconstruction effect with Sr-HAP is fairly satisfactory.

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AnimalsApatitesFacial BonesImplants, ExperimentalMandibleMandibular ProsthesisModels, AnimalRabbitsStrontiumEnglish AbstractJournal Article

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Y Gu, D Liao, Z Zhou. 2001. [The experimental study of Sr-HAP on reconstructing mandibular bone defect].. https://pubmed.ncbi.nlm.nih.gov/11718006/

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