Gene expression profiling of aging using DNA microarrays.

Richard Weindruch; Tsuyoshi Kayo; Cheol Koo Lee; Tomas A Prolla

doi:10.1016/s0047-6374(01)00344-x

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Gene expression profiling of aging using DNA microarrays.

Richard Weindruch·Tsuyoshi Kayo·Cheol Koo Lee·Tomas A Prolla

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Abstract

We have previously employed high density oligonucleotide arrays representing thousands of genes to determine the gene expression profile of the aging process in skeletal muscle (gastrocnemius) and brain (cerebellum and neocortex) of male C57BL/6 mice. Specific gene expression profiles are associated with the aging process of individual organs, and caloric restriction can prevent or retard the establishment of these gene expression alterations. The use of DNA microarrays may provide a new tool to measure biological age on a tissue-specific basis and to evaluate at the molecular level the efficacy of interventions designed to retard the aging process.

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Aging Animals Brain Energy Intake Gene Expression Gene Expression Profiling Macromolecular Substances Male Mice Mice, Inbred C57BL Muscle, Skeletal Oligonucleotide Array Sequence Analysis Proteins Transcription, Genetic Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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Richard Weindruch, Tsuyoshi Kayo, Cheol Koo Lee, Tomas A Prolla. 2002. Gene expression profiling of aging using DNA microarrays.. https://doi.org/10.1016/s0047-6374(01)00344-x

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