PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 11724516

Current topics on immunoadsorption therapy.

S Nakaji
View original source ↗Export metadata ↓

Abstract

Immunoadsorption therapy has become popular for the treatment of various autoimmune diseases as the number of clinically available immunoadsorption columns increases. Immunoadsorption columns for plasma perfusion or direct hemoperfusion available for clinical use such as the Immusorba TR and PH, Selesorb, Prosorba, Immunosorba, Ig-Therasorb, and Medisorba MG are reviewed in the first part of this article. The peptide columns which immobilize peptides as the ligands are described in the second half. The peptide column has the potential to deliver specific adsorbents if a peptide is appropriately designed to remove the pathogenic substances specifically responsible for the given disease.

Explore related subjects

Autoimmune DiseasesHemoperfusionHumansImmunosorbent TechniquesMyasthenia GravisPemphigusPlasmapheresisJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

S Nakaji. 2001. Current topics on immunoadsorption therapy.. https://doi.org/10.1046/j.1526-0968.2001.00360.x

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2003

Autoimmune subepidermal bullous skin diseases: the impact of recent findings for the dermatopathologist.

In recent years improved knowledge of the mechanisms of intercellular and cell-matrix adhesion has led to better understanding of the blistering process in many bullous dermatoses. The wide characterisation of adhesion molecules has partially changed some traditional views and invariably has made the routine work of the pathologist more complex. If understanding cell-cell cohesion structures such as desmosomes and adherens junctions is complex enough, the cell-matrix adhesion structures, such as hemidesmosomes and their structural analogues on the basement membrane and superficial dermis, are even more complex. Defects of such structures cause the subepidermal bullous diseases in which there has been most characterisation of the adhesion molecules and has also led to the discovery of new diseases (e.g. p200 pemphigoid). Most of the antigens are also the targets for mutations seen in patients with the inherited type of epidermolysis bullosa, a group of rare blistering genodermatoses. Another important aspect of bullous skin conditions is the more accurate definition of the role of the different inflammatory cells involved in triggering, development and maintenance of these diseases. Recent studies have outlined the important role of T-cell lymphocytes and their cytokines in their pathogenesis. All these studies, based mainly on highly sophisticated ultrastructural and molecular biology techniques, have updated our knowledge of the pathogenesis of blistering diseases. Nevertheless, the diagnostic characterisation of bullous diseases remains sometimes difficult, and some pathological features and mechanisms still represent an enigma. Diseases such as bullous pemphigoid and cicatricial pemphigoid, or anti-laminin cicatricial pemphigoid and acquired bullous epidermolysis share the same molecular target but have very different clinical manifestations. Explaining this phenomenon, probably linked to different expressions of MHC, is one of the challenges for the future.

Autoimmune Diseases↗