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Cell biology. TAPping into mRNA export.

M J Moore·M Rosbash
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Abstract

There seem to be numerous pathways for exporting mRNAs from the nucleus to the cytoplasm. But working out which set of export adaptors and receptors transport individual mRNAs has been very difficult. In a Perspective, Moore and Rosbash discuss a new strategy using cell-penetrating peptide inhibitors for unraveling the routes of mRNA export in living cells (Gallouzi and Steitz).

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AnimalsAntennapedia Homeodomain ProteinAntigens, SurfaceBiological TransportCell Membrane PermeabilityCell NucleusCytoplasmELAV ProteinsELAV-Like Protein 1Fatty Acids, UnsaturatedGene Products, revHIVHomeodomain ProteinsHumansKaryopherinsNeuropeptidesNuclear ProteinsNucleocytoplasmic Transport ProteinsPeptide FragmentsProtein BindingProtein Structure, TertiaryRNA, MessengerRNA-Binding ProteinsReceptors, Cytoplasmic and NuclearSaccharomyces cerevisiae ProteinsTranscription Factorsrev Gene Products, Human Immunodeficiency VirusExportin 1 ProteinJournal Article

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M J Moore, M Rosbash. 2001-11-30. Cell biology. TAPping into mRNA export.. https://doi.org/10.1126/science.1067676

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