A rapid test for sickle hemoglobin.

T Asakura; M E Segal; S Friedman; E Schwartz

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PubMed · 1173442

A rapid test for sickle hemoglobin.

T Asakura·M E Segal·S Friedman·E Schwartz

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Abstract

Vigorous shaking of oxygenated sickle hemoglobin (Hb S) in solution causes precipitation of the hemoglobin. This unusual property of Hb S forms the basis of a simple test for the presence of Hb S. Comparison of results of this test with those from cellulose acetate electrophoresis in blood samples from 599 patients showed no false-positive or false-negative results. The group tested included 55 persons with sickling disorders and 47 others with unusual hemoglobin patterns. This test may be used to confirm the presence of Hb S or to establish the diagnosis of sickling disorders rapidly in the clinic or at the bedside.

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Anemia, Sickle Cell Black People Chemical Precipitation Electrophoresis False Negative Reactions False Positive Reactions Hemoglobin, Sickle Hemoglobins, Abnormal Humans Informed Consent Methods Phenotype Thalassemia Journal Article Research Support, U.S. Gov't, Non-P.H.S.

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T Asakura, M E Segal, S Friedman, E Schwartz. 1975-07-14. A rapid test for sickle hemoglobin.. https://pubmed.ncbi.nlm.nih.gov/1173442/

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