Fluidized bed design parameters affecting novel lactic Acid downstream processing.

A V Sosa; P R Córdoba; N I Perotti

doi:10.1021/bp010089s

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Fluidized bed design parameters affecting novel lactic Acid downstream processing.

A V Sosa·P R Córdoba·N I Perotti

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Abstract

Lactic acid purification was directly done from fermentation utilizing a fluidized bed column refilled with a strong anionic exchange resin. The purpose of this work was to study the influence of two important design parameters, bed-diameter (D) and bed-height (H), in the lactic acid binding and elution capacity of the matrix. By changing the settled bed height from 2.5 to 5 cm for each diameter of column analyzed it was possible to obtain an 50% increase in the binding capacity of the resin in all experiments. This fact was attributed to a higher contact time between the culture broth and the anionic resin produced by the increase of back mixing and lactic acid residence time.

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Adsorption Algorithms Anion Exchange Resins Bacteriological Techniques Bioreactors Culture Media Fermentation Lactic Acid Lacticaseibacillus casei Resins, Synthetic Journal Article Research Support, Non-U.S. Gov't

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A V Sosa, P R Córdoba, N I Perotti. Fluidized bed design parameters affecting novel lactic Acid downstream processing.. https://doi.org/10.1021/bp010089s

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