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DNA cleavage by aromatic amines.

Philip M Warner·Jiwei Qi·Bin Meng·Gang Li·Longfei Xie·Ahmed El-Shafey·Graham B Jones
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Abstract

A series of aryl amines was found to induce cleavage of DNA. Subsequent refinement led to an efficient family of dimeric derivatives capable of cleavage at low concentration. Initial investigations suggest this is an unprecedented mode of DNA cleavage, which may be ultimately applied to the development of sequence-specific agents.

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AminesAntineoplastic AgentsBacteriophagesDNADNA DamageDimerizationHydrolysisStructure-Activity RelationshipJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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Philip M Warner, Jiwei Qi, Bin Meng, Gang Li, Longfei Xie, Ahmed El-Shafey, Graham B Jones. 2002-01-07. DNA cleavage by aromatic amines.. https://doi.org/10.1016/s0960-894x(01)00688-6

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