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The exocyst is a Ral effector complex.

Serge Moskalenko·Dale O Henry·Carine Rosse·Gladys Mirey·Jacques H Camonis·Michael A White
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Abstract

Delivery of cytoplasmic vesicles to discrete plasma-membrane domains is critical for establishing and maintaining cell polarity, neurite differentiation and regulated exocytosis. The exocyst is a multisubunit complex required for vectorial targeting of a subset of secretory vesicles. Mechanisms that regulate the activity of this complex in mammals are unknown. Here we show that Sec5, an integral component of the exocyst, is a direct target for activated Ral GTPases. Ral GTPases regulate targeting of basolateral proteins in epithelial cells, secretagogue-dependent exocytosis in neuroendocrine cells and assembly of exocyst complexes. These observations define Ral GTPases as critical regulators of vesicle trafficking.

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AnimalsCaco-2 CellsCarrier ProteinsCell PolarityExocytosisFungal ProteinsGTPase-Activating ProteinsHeLa CellsHumansMembrane ProteinsPC12 CellsPhospholipase DProtein TransportRatsSecretory VesiclesSignal TransductionVesicular Transport Proteinsral GTP-Binding ProteinsJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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Serge Moskalenko, Dale O Henry, Carine Rosse, Gladys Mirey, Jacques H Camonis, Michael A White. 2002. The exocyst is a Ral effector complex.. https://doi.org/10.1038/ncb728

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