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Alternative splicing and genome complexity.

David Brett·Heike Pospisil·Juan Valcárcel·Jens Reich·Peer Bork
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Abstract

Alternative splicing of mRNA allows many gene products with different functions to be produced from a single coding sequence. It has recently been proposed as a mechanism by which higher-order diversity is generated. Here we show, using large-scale expressed sequence tag (EST) analysis, that among seven different eukaryotes the amount of alternative splicing is comparable, with no large differences between humans and other animals.

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Alternative SplicingAnimalsCattleExpressed Sequence TagsGenetic VariationGenomeHumansMiceRNA, MessengerRatsJournal Article

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David Brett, Heike Pospisil, Juan Valcárcel, Jens Reich, Peer Bork. 2001-12-17. Alternative splicing and genome complexity.. https://doi.org/10.1038/ng803

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The Role of Small Segmental Duplications in Generating Identical Isoforms Through Alternative Splicing Sites.

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