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Thermosensitive polymer-modified liposomes.

K Kono
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Abstract

Temperature-sensitive liposomes are considered to be a promising tool to achieve site-specific delivery of drugs. These liposomes have been prepared using lipids whose membranes undergo a gel-to-liquid crystalline phase transition a few degrees above physiological temperature. However, recently, temperature-sensitization of liposomes has been attempted using thermosensitive polymers. So far, functional liposomes whose contents release behavior, surface properties, and affinity to cell surface can be controlled in a temperature-dependent manner, have been developed according to this strategy. The design and function of these thermosensitive polymer-modified liposomes have been outlined in this review.

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AnimalsDrug Delivery SystemsHot TemperatureHumansLiposomesPolymersSurface PropertiesTissue FixationJournal ArticleReview

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K Kono. 2001-12-31. Thermosensitive polymer-modified liposomes.. https://doi.org/10.1016/s0169-409x(01)00204-6

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