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Why do cells have multiple error-prone DNA polymerases?

E C Friedberg
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Abstract

Recent years have witnessed the emergence of a plethora of so-called novel DNA polymerases in both eukaryotic and prokaryotic cells. Many of these DNA polymerases are characterized by poor replicational fidelity and low processivity, and are devoid of 3' --> 5' exonuclease activity. This article describes the discovery of these error-prone polymerases and what is known about their biological function.

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AnimalsDNA RepairDNA ReplicationDNA-Directed DNA PolymeraseHumansJournal ArticleResearch Support, U.S. Gov't, P.H.S.Review

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BibTeXRIS

E C Friedberg. 2001. Why do cells have multiple error-prone DNA polymerases?. https://doi.org/10.1002/em.1059

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