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TGF-beta flips the Myc switch.

A Orian·R N Eisenman
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Abstract

Although transforming growth factor-beta (TGF-beta) can affect cell cycle arrest, not much molecular detail is known about how TGF-beta-dependent arrest is mediated. Two recent papers shed some light on how this is accomplished. Orian and Eisenman discuss how Myc interacts with Miz-1 to block the expression of a cell cycle inhibitory protein, p15(INK4b), and how TGF-beta is able to unblock Myc-dependent repression of Miz-1.

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AnimalsCell CycleCell DivisionGene Expression RegulationGenes, mycHumansSignal TransductionTransforming Growth Factor betaJournal ArticleReview

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A Orian, R N Eisenman. 2001-06-26. TGF-beta flips the Myc switch.. https://doi.org/10.1126/stke.2001.88.pe1

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