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Optic neuritis after anthrax vaccination.

John B Kerrison·David Lounsbury·Charles E Thirkill·R Gary Lane·Martha P Schatz·Renata M Engler
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Abstract

OBJECTIVE: To report the occurrence of optic neuritis after anthrax vaccination in two patients. DESIGN: Observational case reports, review of literature. METHODS: Description of clinical history, examination, neuroimaging, and further studies in two patients experiencing optic neuritis in temporal association with anthrax vaccination. MAIN OUTCOME MEASURES: Visual acuity, visual fields. RESULTS: Two patients, 39 and 23 years of age, were seen with acute optic neuritis 1 month and 2 weeks, respectively, after anthrax booster vaccination and successfully treated with intravenous methylprednisolone. The first patient had a typical presentation and course of unilateral retrobulbar optic neuritis with excellent visual recovery. The second patient had a bilateral anterior optic neuritis and has required chronic immunosuppression to maintain his vision. Retinal and optic nerve autoantibodies were present in the second patient. No cross-reactive epitopes between anthrax vaccine and retina/optic nerve were identified. CONCLUSION: Optic neuritis is a potential adverse reaction of anthrax vaccination.

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Acute DiseaseAdultAnthrax VaccinesBrainHumansMagnetic Resonance ImagingMaleOptic NeuritisVaccinationVisual AcuityVisual FieldsCase ReportsJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.Review

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BibTeXRIS

John B Kerrison, David Lounsbury, Charles E Thirkill, R Gary Lane, Martha P Schatz, Renata M Engler. 2002. Optic neuritis after anthrax vaccination.. https://doi.org/10.1016/s0161-6420(01)00844-2

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