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PubMed · 11774212

[Analysis on HLA-E polymorphism in Shanghai Han population].

L Zhao·L Fan·J Yang·F Yao·L Xu
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Abstract

OBJECTIVE: To investigate the distribution of HLA-E alleles in Chinese Han in Shanghai area. METHODS: HLA-E alleles were assigned by using a PCR/SSO method in 201 random healthy individuals from Shanghai region. HLA-A,-B antigens typing was carried out with NIH standard microlymphocytoxicy method. RESULTS: Three alleles of HLA-E could be detected in this population. The E*0101 is the most common allele with a frequency of 42.29%, followed by E*01032 and E*01031 with 32.84% and 24.88% respectively. No E*0102 and E*0104 could be detected in all of the individuals. The analysis of linkage on two loci between HLA-E and HLA-A or -B showed that no significant difference could be found between expected frequencies and observed frequencies excepting B15/E*01032 and A2/E*01032. CONCLUSION: The allele frequencies of HLA-E are 42.29% for E*0101, 24.88% and 32.84% for E*01031 and E*01032 respectively in Shanghai Chinese. No extensive linkage disequilibrium was found between HLA-E and HLA-A or -B locus.

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AllelesChinaDNAGene FrequencyHLA AntigensHLA-A AntigensHLA-B AntigensHistocompatibility Antigens Class IHumansPolymorphism, GeneticHLA-E AntigensEnglish AbstractJournal Article

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L Zhao, L Fan, J Yang, F Yao, L Xu. 2001. [Analysis on HLA-E polymorphism in Shanghai Han population].. https://pubmed.ncbi.nlm.nih.gov/11774212/

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