Multisite phosphorylation and the countdown to S phase.

R J Deshaies; J E Ferrell

doi:10.1016/s0092-8674(01)00620-1

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Multisite phosphorylation and the countdown to S phase.

R J Deshaies·J E Ferrell

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Abstract

Remarkably, SCF(Cdc4) ubiquitin ligase binds and ubiquitinates Sic1 decorated with six, but not five, phosphates. This numerical wizardry suggests how analog inputs can be rectified to digital outputs. Unraveling the counting mechanism promises to generate new insights into the architecture of protein nanoprocessors.

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Animals Cell Cycle Proteins Cyclin-Dependent Kinase Inhibitor Proteins Cyclin-Dependent Kinases F-Box Proteins F-Box-WD Repeat-Containing Protein 7 Fungal Proteins Humans Peptide Synthases Phosphorylation S Phase SKP Cullin F-Box Protein Ligases Saccharomyces cerevisiae Proteins Signal Transduction Ubiquitin-Protein Ligases Journal Article Review

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R J Deshaies, J E Ferrell. 2001-12-28. Multisite phosphorylation and the countdown to S phase.. https://doi.org/10.1016/s0092-8674(01)00620-1

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