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PubMed · 11781331

Micro-RNAs: small is plentiful.

Helge Grosshans·Frank J Slack
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Abstract

Two small temporally regulated RNAs (stRNAs)* of approximately 22 nucleotides regulate timing of gene expression during development of the nematode C. elegans. This regulation occurs at a posttranscriptional, presumably translational, level and is distinct from RNA interference (RNAi). One of the two stRNAs, let-7, as well as its target gene, lin-41, are highly conserved even in humans, suggesting a wide employment of stRNA-mediated gene regulation. Recent reports indicate that these two stRNAs are indeed likely to represent only the tip of an iceberg with hundreds or more of additional micro-RNAs (miRNAs) existing in metazoans. miRNAs might thus be previously underestimated key participants in the field of gene regulation.

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AnimalsBase SequenceConserved SequenceGene Expression RegulationGenes, HelminthHumansProtein BiosynthesisRNA PrecursorsRNA, Small CytoplasmicTranscription, GeneticJournal ArticleReview

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Helge Grosshans, Frank J Slack. 2002-01-07. Micro-RNAs: small is plentiful.. https://doi.org/10.1083/jcb.200111033

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