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Abstract

This review summarizes from biological research in obsessive-compulsive disorder. In particular, functional brain imaging studies investigating the effects of Symptom provocation, of behavioral and pharmacological treatment on brain activity and findings from neurochemical studies are presented with regard to the serotonergic System. We discuss a neurobiological model integrating the findings from brain imaging, functional anatomy and behavioral concepts which favors a functional imbalance within the orbitofrontal - basal ganglia - thalamus ciruit and focus on hypothesis for further research.