Cholinergic influences on use-dependent plasticity.

L Sawaki; B Boroojerdi; A Kaelin-Lang; A H Burstein; C M Bütefisch; L Kopylev; B Davis; L G Cohen

doi:10.1152/jn.00279.2001

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PubMed · 11784739

Cholinergic influences on use-dependent plasticity.

L Sawaki·B Boroojerdi·A Kaelin-Lang·A H Burstein·C M Bütefisch·L Kopylev·B Davis·L G Cohen

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Abstract

Motor practice elicits use-dependent plasticity in humans as well as in animals. Given the influence of cholinergic neurotransmission on learning and memory processes, we evaluated the effects of scopolamine (a muscarinic receptor antagonist) on use-dependent plasticity and corticomotor excitability in a double-blind placebo-controlled randomized design study. Use-dependent plasticity was substantially attenuated by scopolamine in the absence of global changes in corticomotor excitability. These results identify a facilitatory role for cholinergic influences in use-dependent plasticity in the human motor system.

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Administration, Cutaneous Cholinergic Fibers Double-Blind Method Electric Stimulation Electromyography Evoked Potentials, Motor Humans Magnetics Motor Cortex Movement Muscarinic Antagonists Muscle, Skeletal Neuronal Plasticity Scopolamine Sensory Thresholds Thumb Clinical Trial Journal Article Randomized Controlled Trial

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L Sawaki, B Boroojerdi, A Kaelin-Lang, A H Burstein, C M Bütefisch, L Kopylev, B Davis, L G Cohen. 2002. Cholinergic influences on use-dependent plasticity.. https://doi.org/10.1152/jn.00279.2001

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