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Serotonergic targets in depression.

Derek N Middlemiss·Gary W Price·Jeannette M Watson
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Abstract

Serotonin reuptake inhibitors have proved to be a very effective treatment for depression and have strengthened the hypothesis that impaired 5-hydroxytryptamine (5-HT) neurotransmission may contribute to the underlying cause of depressive disorders. Extensive research has been carried out to investigate other 5-HT targets associated with the disease and studies involving combination treatments with selective serotonin reuptake inhibitors and 5-HT(1A) receptor ligands are currently being carried out in the clinic. Whether other 5-HT receptor subtypes are involved in the aetiology of depression remains to be seen.

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AnimalsAntidepressive AgentsDepressionDrug Delivery SystemsHumansReceptors, SerotoninJournal ArticleReview

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Derek N Middlemiss, Gary W Price, Jeannette M Watson. 2002. Serotonergic targets in depression.. https://doi.org/10.1016/s1471-4892(01)00116-3

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