Technologically advanced cancer modeling in mice.

David A Tuveson; Tyler Jacks

doi:10.1016/s0959-437x(01)00272-6

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PubMed · 11790563

Technologically advanced cancer modeling in mice.

David A Tuveson·Tyler Jacks

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Abstract

Multiple approaches now exist for the generation of genetically engineered murine cancer models. These new models utilize latent, conditional and inducible alleles to better mimic the in vivo setting in which sporadic human cancers occur. The murine tumor models are beginning to reveal mysteries of tumorigenesis, such as the role of the tumor microenvironment and the dependence of tumors on continuous oncogenic stimulation.

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Animals Disease Models, Animal Gene Targeting Genes, Tumor Suppressor Genetic Engineering Genome Mice Mice, Transgenic Models, Genetic Neoplasms Oncogenes Journal Article Research Support, Non-U.S. Gov't Review

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David A Tuveson, Tyler Jacks. 2002. Technologically advanced cancer modeling in mice.. https://doi.org/10.1016/s0959-437x(01)00272-6

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