PubMed Health⌕ Search

PubMed · 11790603

Recent developments in combinatorial organic synthesis.

Abstract

The level of sophistication of combinatorial synthesis continues to increase at a heady pace. Fairly complex target molecules are now being assembled combinatorially using a broad palette of organic reactions both in solution- and solid-phase. This review highlights academic and industrial examples of combinatorial synthesis published within the last year. Recent advances in small-molecule synthesis are outlined, ranging from simple acyclic scaffolds to complex natural products.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

A Ganesan. 2002-01-01. Recent developments in combinatorial organic synthesis.. https://doi.org/10.1016/s1359-6446(01)02087-6

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

Catalytic asymmetric synthesis of both syn- and anti-3,5-dihydroxy esters: application to 1,3-polyol/alpha-pyrone natural product synthesis.

[reaction: see text] We describe a catalytic asymmetric synthesis of both syn- and anti-3,5-dihydroxy esters. The method relies upon catalytic asymmetric epoxidation of alpha,beta-unsaturated imidazolides and amides, using lanthanide-BINOL complexes, and diastereoselective reduction of ketones. The method was applied to the enantioselective syntheses of 1,3-polyol/alpha-pyrone natural products 9a, 9b, and strictifolione (10). The absolute stereochemistry of 9a and 9b was also determined.

Biological Factors↗