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Alcohol and false recognition: a dose-effect study.

M Z Mintzer·R R Griffiths
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Abstract

RATIONALE: The pattern of acute memory impairment produced by alcohol is similar to that produced by the benzodiazepines. However, in contrast to demonstrations that benzodiazepines decrease false recognition rates, results of a recent study suggest that a low dose of alcohol increases false recognition rates; false recognition refers to the phenomenon of mistakenly claiming that one has been exposed previously to a novel item. OBJECTIVE: This study was designed to examine the acute dose-effects of alcohol on false recognition. METHODS: Effects of alcohol (0.27 and 0.60 g/kg) on performance in the Deese/Roediger-McDermott false recognition paradigm were examined in a repeated measures placebo-controlled double-blind design in 18 healthy volunteers. RESULTS: The 0.60 g/kg dose of alcohol significantly reduced true recognition rates (measured by hit rate) and induced a more conservative response bias (measured by C) relative to placebo; however, neither alcohol dose significantly impaired participants' sensitivity in discriminating between old and new words (d'). Neither alcohol dose affected false recognition rates. CONCLUSIONS: Effects of alcohol on false recognition and on response bias may differ from those observed previously with benzodiazepines. A direct comparison at equivalent doses will be necessary to draw conclusions about qualitative differences between alcohol and benzodiazepines.

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AdultAlcohol DrinkingAnalysis of VarianceCentral Nervous System DepressantsCross-Over StudiesDose-Response Relationship, DrugDouble-Blind MethodFemaleHumansMaleMiddle AgedRecognition, PsychologyJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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M Z Mintzer, R R Griffiths. 2001-09-06. Alcohol and false recognition: a dose-effect study.. https://doi.org/10.1007/s002130100893

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