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PubMed · 11797675

Engineering tolerance into transplanted beta cell lines.

B Thorens·P Dupraz·S Cottet
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Abstract

In this paper we explore the possibility of improving, by genetic engineering, the resistance of insulin-secreting cells to the metabolic and inflammatory stresses that are anticipated to limit their function and survival when encapsulated and transplanted in a type 1 diabetic environment. We show that transfer of the Bcl-2 antiapoptotic gene, and of genes specifically interfering with cytokine intracellular signaling pathways, greatly improves resistance of the cells to metabolic limitations and inflammatory stresses.

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AnimalsCell DivisionCell LineGenes, bcl-2Genetic EngineeringImmune ToleranceInterferon-gammaInterleukin-1Islets of Langerhans TransplantationSignal TransductionTumor Necrosis Factor-alphaJournal Article

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B Thorens, P Dupraz, S Cottet. 2001. Engineering tolerance into transplanted beta cell lines.. https://doi.org/10.1111/j.1749-6632.2001.tb03838.x

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