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PubMed · 11798136

Mycobacterium-specific human CD8 T cell responses.

M R Klein·A Fox
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Abstract

Tuberculosis (TB) remains a global health problem. There is an intense effort to identify correlates of protective immunity and to design new TB vaccines. CD8 T cells are thought to play a significant role in controlling Mycobacterium tuberculosis infection. Relatively little has been published about the antigens and epitopes targeted by mycobacteria-specific CD8 T cells. Here we present an update of our 1999 overview of human CD8 T cell epitopes in mycobacterial antigens and discuss related issues relevant to TB diagnosis and vaccine development.

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Amino Acid SequenceAnimalsAntigens, BacterialBCG VaccineCD8-Positive T-LymphocytesDisease Models, AnimalEpitopesGenetic VariationHumansImmunologic TestsIn Vitro TechniquesMolecular Sequence DataMycobacterium tuberculosisPhenotypePrognosisTuberculosis, PulmonaryVaccines, SubunitJournal ArticleResearch Support, Non-U.S. Gov'tReview

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M R Klein, A Fox. 2001. Mycobacterium-specific human CD8 T cell responses.. https://pubmed.ncbi.nlm.nih.gov/11798136/

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